Bile acids differentially impact on platelet activation

Introduction Platelets are well-established mediators of inflammatory responses throughout the body. Increased platelet activity occurs in the intestinal mucosa in conditions of Inflammatory Bowel Disease (IBD), where it may contribute to the mucosal fibrosis associated with these diseases. The bile acids, ursodeoxycholic acid (UDCA), deoxycholic acid (DCA) and tauroursodeoxycholic acid (TUDCA) were shown to regulate inflammatory responses in the intestine. The aim of this study is to analyse the impact of these bile acids on platelet activation.